Histopathological Changes of Zebrafish (Branchydanio Rerio) Brain with Treated Triclosan and Recovered by Using Garlic Extract and Vitamin C

Author(s): D. Nagarajan, S. Sridevi and T. Ramesh Kumar

Abstract: Triclosan is a synthetic, broad spectrum of biocide and act as a antimicrobial agent. Triclosan has been extensively used along the years in a diversity of tropical application. The present study was carried out to study the histopathology of brain in zebra fish Brachydanio rerio (Ham) which are exposed to triclosan (0.32mg/l) for 28 days. The histopathological changes of brain were observed microscopically showed increasing degree of damage in the tissue correlation with the concentration of triclosan and the control groups exhibited a normal architecture. The histopathological studies have been conducted to establish the causal relationships between contaminant and exposure and other various biological responses. The present investigations have also been proved to be a sensitive tool to detect direct effects of chemical compounds within target organs of fish in the laboratory experiment such analysis appears to be a very sensitive parameter and is crucial in determining cellular changes that may occur in target organs, such as the brain.

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