Solubility Enhancement of Sertraline by Solvent Evaporation Co-Crystal Technique

Author(s): Bandela Anusha* and M.Sunitha Reddy

Abstract: Objective: Sertraline belongs to a class of antidepressant agent known as selective serotonin reuptake inhibitors (SSRIs). It is a class two drug, low solubility and high permeability. The aim of this study is to enhance the aqueous solubility of sertraline by solvent evaporation co-crystal technique. Methods: In this research, co-crystals formation between sertraline (drug) and aromatic acids benzoic acid, salicylic acid and oxalic acid (co-formers) in quimolar ratio have been prepared by solvent evaporation method with methanol, acetonitrile and diethyl ether as solvents. Co-crystal formation of sertraline-benzoic acid, and sertraline-salicylic acid sertraline-oxalic acid was characterized by powder x-ray diffraction (PXRD), Fourier transform infrared (FTIR) spectroscopy, fluorescence microscopy, solubility and dissolution methods. Results: The XRD patterns of sertraline benzoic acid co-crystals were different from pure components. The solubility test showed the sertraline-benzoic acid co-crystals has 14 folds higher than pure sertraline. The dissolution rate test showed that sertraline-benzoic acid co-crystals has percentage of dissolved after 60 min higher than pure sertraline. Conclusion: Sertraline-benzoic acid co-crystals can increase the solubility and dissolution rate of sertraline.

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