Pharmacological Evaluation of Liquorice for Various Dermatological Disorders in Mice

Author(s): Jada Naga Lakshmi*, P. Supriya, P. Lakshmi Soumya, P. Vandana, A. Narendra Babu

Abstract: Objective of present study was to evaluate the anti- psoriatic and anti-acne activity of liquorice in mice. Background: Liquorice (Glycyrrhiza sp.) is one of the oldest and most frequently prescribed herbs in traditional Chinese medicine. Methods: The anti-psoriatic effect of liquorice was assessed in mouse tail model for psoriasis was developed by exposed mice tail to UV light for 14days. The anti-acne activity of liquorice was assessed in oxazolone induced activity on sebaceous glands of rats’ model. The animals were dividing into four groups treated as group-1, group-2, group-3, and group-4, mice received normal ointment base, salicylic acid ointment, 1% liquorice and 2% liquorice of liquorice respectively up one week on tail region. Results: On all four groups after exposing to U.V light animals produce psoriatic lesions with characterised by itching and scaling. Epidermal thickness of disease induced animals (0.775****±0.0703), epidermal thickness of 1% liquorice treated is (2.9038****±0.064) 2% liquorice treated is (3.105****±0.0629). Histopathological examination of tail belonging to the disease control revealed prominent epidermal hyperplasia and marked infiltration of inflammatory cells consisting of monocytes, granulocytes and macrophages, mainly into the dermis and some into epidermis. Conclusion: 2% liquorice significantly increased epidermal thicknesses with respectively as compared to the remaining group animals. 2% liquorice having significant anti-psoriatic activity against UV induced psoriasis in mice. Volume of sebaceous gland and thickness was found to be significantly, increased thickness and decreased sebaceous gland secretions volume in the disease model as compared to the control animal.

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