Synthesis and In Vitro Antimicrobial Screening of 3-Acetyl-4-Hydroxycoumarin Hydrazones

Author(s): Khursheed Ahmed*, Sreenivasulu Enumula, Anees Pangal, Ishtiaq Jeelani, Madhavi Rane, Ganesh Mahangade, Vasim Patel

Abstract: We report the organic syntheses of some new 3-acetyl-4-hydroxycoumarin hydrazones with different acid hydrazides. The structures of the synthesized compounds have been established on the basis of physical and spectral data. They show a prominent absorption of -(C=N-) in FTIR a common peak of 4-OH at 15.90 ppm in the form of broad singlet. The antibacterial activity of synthesized compound is compared to antibacterial activity of the standard antibiotics streptomycin. All the synthesized compounds are moderately active when compared with standard streptomycin.

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