Evaluation of Hepatoprotective Activity of Ethanolic Extract of Sida Rhombifolia Against CCl4 Induced Hepatotoxicity in Rats

Author(s): M. Srikanth, M. Prasad Rao, Jampani Jyothsna, M. Bhargavi Thanuja, K. Venkaiah, U. Koteswar Rao and K. Venkateswarlu

Abstract: Sida rhombifolia is a valuable herb belonging to the family Malvaceae, and widely distributed in world. It is popularly known as “Arrow leaf” and various parts of the plant are used in the treatment of skin problem, bronchitis, antifungal, eye-disease, cancer, diabetes, digestive, diuretic, emetic, expectorant, laxative, stimulant, stomachic, uterine tonic and urinogenital infection etc. Here in this study an attempt was made to evaluate the Hepatoprotective activity of ethanolic extract of leaves of Sida rhombifolia (200, 400mg/kg). Hepatotoxicity was induced in albino rats using Carbon tetrachloride (CCl4 - 0.5ml/kg in1:1 ratio with Olive oil), and Silymarin (50mg/kg) was taken as the Standard Drug. The biological markers like Aspartate Transaminase, Alanine Transaminase, Alkaline Phosphatase, Total bilirubin and Total Protein are monitored for changes caused due to CCl4 induced Hepatotoxicity. It was observed that the leaf extract of Sida rhombifolia decreased the elevated levels of the hepatic enzymes significantly when compared to the standard (p<0.001). Thus the results suggest that the ethanolic extract of leaf of Sida rhombifolia is a reliable Hepatoprotective agent.

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