Actinobacterial Species Selection for Production of Antimicrobial Peptide using PROMETHEE GAIA

Author(s): Palanisamy Priya Dharsini* and Palanisamy Selvamani

Abstract: The investigation of robust antimicrobial peptides from the natural environment has promptly been boosting strength with the upsurge in multi-drug resistant pathogens. Actinobacteria are assorted cluster of Gram positive, high GC content and filamentous bacteria and considered as an admirable elaborators of therapeutic products. In the present study, antibacterial potential of crude peptides has been evaluated by initial screening of thirteen actinobacterial isolates. Isolate PPD 6 is the most promising candidate for the antimicrobial peptide production based on decision vector through key physical and chemical parameters as temperature, pH (Buffers) and antibiotic resistance as a competent of multi-criteria decision analyses (MCDA) and ranking with Preference Ranking Organisation Method for Enrichment Evaluation (PROMETHEE) and Graphical Analysis for Interactive Assistance (GAIA) analysis. Biological activity was analysed in the presence of enzymes, chemicals, solvents and metals, no loss in their activity were recorded.

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