Novel Approach on Herbal Drug Delivery System: Phytosome A Brief Overview

Author(s): Rupali Joshi* and Manoj Bhardwaj

Abstract: Aim-The term phytosome is derived from two words, “Phyto” means plant and “Some” means cell. Phytosome is a patented technology developed by leading industrialist in phyto-pharmaceuticals to produce lipid drug molecular complexes. Complexing the polyphenolic phytoconstituents in the molar ratio with phosphatidyl choline results in a new herbal drug delivery system, known as “Phytosome”. Method-Phytosomes were prepared by reacting the herbal extract in an aprotic solvent such as methylene chloride, dioxane and ethyl acetate with the phospholipid such as phosphotidylcholine, phosphatidylethanolamine or phosphatidylserine dissolved in the same solvent. After solubilization has been completed, the complex compounds are isolated by removing the solvent under vacuum evaporator, by freeze drying or by precipitation with non-solvents such as n-hexane. Results-Phytosome contains herbal or phyto-constituent entrapped in an aqueous core surrounded by a lipid bilayer, consists of phosphotidyl-choline. Phytosomes loaded leads to products that are highly absorbed and produces higher results as compare, to the conventional herbal extracts. Conclusion-Thus, the obtained complexes are lipophilic in character and soluble in a polar and aprotic solvent, in which the individual components of complexes are normally insoluble.

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