Free Radical Scavenging Activity of Various Extracts of Aerial Parts of Macaranga peltata (Roxb.): An In Vitro Evaluation

Author(s): Bheemreddy Thrinitha*, P. Manichandrika and R. Murali

Abstract: Macaranga peltata (Roxb.) is belongs to the family Euphorbiaceae is commonly known as Chandwar is a medicinal plant associated with diverse biological activities. In the presented study aerial parts of different extracts of the plant was evaluated for its in-vitro antioxidant potential by DPPH free radical scavenging activity, superoxide scavenging activity taking ascorbic acid and quercetin as the standard and total phenol content respectively. An IC50 value was found that methanolic extract of Macaranga peltata is more effective in DPPH radical, superoxide radical scavenging activity than that of ethyl acetate and petroleum ether extract. The methanolic extract of Macaranga peltata and ascorbate exhibited free radical scavenging activity possessing IC50 values 188μg/ml and 66μg/ml (DPPH Free Radical Scavenging Activity). 210μg/ml and 60μg/ml (Superoxide Scavenging Activity) respectively. Moreover, the results were observed in a concentration dependent manner. In addition, the methanolic and ethyl acetate extract of Macaranga peltata was found to contain a noticeable amount of total phenols, which play a major role in controlling antioxidants. All the above invitro studies clearly indicate that the methanolic extract of Macaranga peltata has a significant antioxidant activity. These invitro assays indicate that this plant extracts is a better source of natural antioxidant, which might be helpful in preventing the progress of various oxidative stresses.

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