Volume 9, Issue 3, July 2019

Probiotics: Potential Bio-Therapeutics for Lowering Cholesterol

Author(s): Mahadik A. K., Vemula A. N
Abstract: Hypercholestramia, accumulation of high cholesterol in the blood vessels which create blocks and result in heart attack. 34% of deaths in India is due to accumulate of cholesterol. To overcome the problem, this research focus on to regulate and maintain the level of cholesterol. Isolation of Lactobacillus on MRS medium was carried out using dairy products as sample. Biochemical characterization of isolates belongs to Lactobacillus Spp. Probiotic properties like haemolytic activity, bile salt tolerance assay, cell surface hydrophobicity and anti-microbial susceptibility was tested. Lactobacillus were non-haemolytic indicating the non-virulence nature and application as probiotics. Cell surface hydrophobicity and bile salt hydrolase activity benefits the Lactobacillus by enhancing its resistance to conjugated bile salts and increasing its survival in the gastrointestinal tract. Lactobacilli strains sustain in gut indicates their ability to retain during the therapy. Isolates CS2, CS3, MS1 and MS5 were proved to possess probiotic characters. MS5 was found efficient to hydrolyze bile and inhibits the cholesterol formation at initial stages leading to low levels of cholesterol accumulation. MS5 was found to reduce cholesterol up to 90% and proved to be efficient as therapeutic agent.
PAGES: 70-73  |  25 VIEWS  33 DOWNLOADS

How To Cite this Article:

Mahadik A. K., Vemula A. N. Probiotics: Potential Bio-Therapeutics for Lowering Cholesterol. 2019; 9(3): 70-73.