Studies on Antioxidant and Anticancer Potentials of Fruit Pulp Extract of Semecarpus anacardium

Author(s): A.D. Naveen Kumar*, Berihu Haftu and M.V.S. Mahesh Kumar

Abstract: Cellular damage mediated by reactive oxygen species (ROS) has been implicated in the pathogenesis of several diseases. Natural antioxidants have significant importance in human health. Focus towards the natural sources of antioxidants has been increasing these days to fight against the lethal effects of free radicals. Semecarpus anacardium, a medicinal plant of Anacardiaceae family used as remedy in the alleviation of disorders. The present study was focused to evaluate the antioxidant and anticancer potentials aqueous extract of S.anacardium fruit pulp by most accepted methods. The aqueous extract exhibited significant DPPH, hydroxyl radical and nitric oxide scavenging activities. In addition, the aqueous extract also exhibited significant anti-proliferative activity and cathepsin B and MMP-9 inhibitory activities. Therefore, S.anacardium fruits may serve as a novel therapeutic agent for the treatment of radical mediated diseases.

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