Volume 9, Issue 3, July 2019

In Vitro Antidiabetic Activity of Leaf Extracts of Indianthus virgatus (Roxb.) Suksathan and Borchs by Glucose Uptake Method

Author(s): *Sangeetha D N and S. Rajamani
Abstract: Medicinal plants play a key role to cure many diseases from time immemorial. The usage of medicinal plants in traditional medicinal system is the vital process of India. Diabetes Mellitus is a systemic metabolic disease characterized by hyperglycemia, abnormal elevated levels of lipid, and fat in blood and hypoinsulinaemia. The current epidemic of diabetes indicates the need of proper and effective medications that are limited in their potency to have many side effects. Thus, introduction of alternative and complementary medicine is now in picture. Objective: The main objective of this work is to evaluate the in vitro anti diabetic activity of leaf extracts of Indianthus virgatus (Roxb.) Suksathan and Borchs in skeletal muscle cell line. Methods: The in vitro cytotoxicity was performed for leaf extract (Chloroform and Acetone) on L-6 (Rat skeletal muscle) cell line to find toxic concentration of the leaf extract by MTT assay. Glucose uptake activity of test substance was determined in differentiated L-6 cells. Result: In Glucose uptake assay, acetone extract exhibited better activity with higher glucose uptake assay. Glucose uptake rate increased with the increasing concentration of the leaf extract. Conclusion: The results of the current study clearly demonstrated the antidiabetic potency of leaf extracts obtained from Indianthus virgatus (Roxb.) Suksathan and Borchs under in vitro model.
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How To Cite this Article:

*Sangeetha D N and S. Rajamani. In Vitro Antidiabetic Activity of Leaf Extracts of Indianthus virgatus (Roxb.) Suksathan and Borchs by Glucose Uptake Method. 2019; 9(3): 89-96.