Formulation and Evaluation of Valsartan Floating Tablets

Author(s): B. Premkumar*, K. Bindhumadhavi, K. P. Chandralekha, Shaik Asif and A. Srinivasa Rao

Abstract: The present research work was an attempt to formulate and evaluate floating tablet containing valsartan in the form of tablets using polymers like HPMC K100M, Ethyl cellulose, NaHCO3 as gas generating agent. Valsartan, an antihypertensive drug, with an oral bioavailability 23%, short half-life (6 hr) and largely present in unionized form in acidic pH, have been designed to increase gastric residence time and therapeutic efficacy. This can be achieved by fabricating floating tablets which retain in stomach for prolonged time to release the drug. The tablets were formulated by direct compression method. The effect of sodium bicarbonate and citric acid on drug release profile and floating properties were investigated. The tablets were characterized for the pre and post compression parameters such as friability, hardness, thickness, drug content, weight variation, in-vitro buoyancy studies and in-vitro drug release studies and the results were within the limits. The in-vitro drug release studies were carried out in a USP type-II apparatus in 0.1N HCl. Optimized formulation (F1) revealed that tablet was constantly floating in the stomach region of the rabbit, thereby indicating improved gastric retention time for more than 8 h. Consequently, all the findings and outcomes have showed that developed valsartan matrix tablets could be effectively used for floating drug delivery system.

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