DNA Cleavage by Transition Metal Complexes and it’s Applications - A Review

Author(s): Deboshmita Mukherjee and Rajesh Kumar Das*

Abstract: In this review, we briefly summarize recent works done in designing metal complexes that show DNA cleavage activities, via hydrolytic or oxidative mechanisms. Transition metal complexes capable of cleaving DNA can also be used as therapeutic agents. We have focused here mainly on transition metal complexes of Cu+2, Ni+2, Co+2, Mn+2, Fe+2, Zn+2 and Pt+2 that show DNA cleavage activity either in hydrolytic or oxidative pathways. We have also tried to summarise few applications of the transition metal complexes based on DNA cleavage phenomenon. Our future aim is to prepare Cr (III)-BLM complex as like as the other metallo-BLM complexes, that should play a vital role in drug transport, and/or DNA cleavage.

PAGES: 1089-1106  |  207 VIEWS  395 DOWNLOADS