Antitumor and Antioxidant Potential of Ethyl Acetate Extract of Ixora Singaporensis Hort Against Ehrlich Ascites Carcinoma Tumor

Author(s): Amol Kharat, Vidya Nambiar and Kiran R Kharat

Abstract: Ixora singaporensis leaves have been traditionally used for many ailments including cancer. In the present study, anticancer activity of ethyl acetate extract of Ixora singaporensis leaves (EAIS) was evaluated by using in vitro and in vivo methods. Total flavonoid content and total antioxidant capacity of the extract were determined. EAIS was found antiproliferative against the HeLa cells with the IC50 values recorded at 26 ± 0.6 μg/ml. With increase in concentration of extract (EAIS) 200, 300 and 500 mg, 18.6, 32.56 and 55.81 days increase in life span observed, respectively. Percentage of cell viability also decreases with increase in concentration of extracts. The potency of the extract was compared with standard 5- fluorouracil (10 mg/kg i.p.).

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