Estradiol Valerate Dose Determination for PCOS Induction

Author(s): Mukilan Ramadoss, Manibalan Vijayaraman and Angelie Jessica Subbiah

Abstract: Animal model polycystic ovary are used to study the etiological and pathophysiological, perform drug testing and investigative effect of treatment in various ways that are not possible in humans as well as to carry out pre-clinical studies. In order to resemble the pathophysiology of the syndrome several models in various mammalian and primate species have been developed during the decades, each having its own advantages and disadvantages. Estradiol valerate (EV) is utilized to create PCOS by prompting hormone variations from the normal. EV, which is presented as a prodrug, is an ester derived from 17β- estradiol. A single intramuscular infusion of estradiol valerate (EV) in cycling rats brings about loss of oestrus cyclicity, anovulation, and the development of follicular cysts. These progressions showed by the steroid-incited polycystic ovary (PCO) share considerably a lot of the endocrinological and morphological variations as found in human PCOS.

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