Formulation, Optimization and In-Vitro Evaluation of Mouth Dissolving Tablets of Carvedilol by Using Natural Superdisintegrants

Author(s): S. B. Bhanja*, S. Sridhar, M. Sudhakar and B. B Panigrahi and Dillip ku jena

Abstract: The purpose of the present investigation is to formulate, optimize and evaluate of mouth dissolving tablets of Carvedilol, is anti-Hypertensive drug by Direct Compression method using different concentrations of Natural superdisintegrants i.e., Guar gum, Xanthan gum and Starch as (1-6% w/w). The drug-excipient interactions were investigated by FTIR. The prepared tablets were evaluated for micromeritic properties, hardness, friability, weight variation, in-vitro dispersion time, wetting time, water absorption ratio, in-vitro disintegration and in-vitro drug release. All the formulations showed low weight variation with rapid disintegration time and rapid in vitro dissolution. Among the twelve promising formulations (F1-F12), the best formulation, F4 (Guar gum) provided short Wetting time of 57±1.25sec, water absorption ratio 16±0.85%, in-vitro dispersion time of 40 sec and in vitro disintegration of 52±1.14sec and in-vitro drug release i.e. 98.8% at the end of 10 min. The disintegration time was found to linearly decrease with the increase in the amount of natural superdisintegrant. It was concluded that there are no much significant changes in any values which indicated that the formulation, F4, was considered to be highly stable and mouth dissolving tablets of Carvedilol can be successfully formulated by natural superdisintegrant addition method with improved patient compliance.

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