EVALUATION OF ANTI HYPERLIPIDEMIC ACTIVITY IN RODENTS USING LEAF EXTRATS OFCLERODENDRUM SERRATUM BY FOOD INDUCED OBESITY IN RATS

Author(s): *M.Venkateswara Rao and R.S.Venkatesh

Abstract: The Hypolipedemic effect of various extracts of clerodendrum serratum was investigated in rats suffering from high cholesterol, diet induced hyperlipidemia and the phytochemicals in the extracts were analysed. The high-cholesterol diet caused a significant increase in total lipids, total cholesterol (TC), total triglycerides (TG), low-density lipoprotein cholesterol (LDL-C), and the atherogenic index, whereas the level of high-density lipoprotein cholesterol (HDL-C) was significantly decreased. The animals were divided into 6 groups where 2 used as test, 1 for standard, 1 for control, 1 for diet induced hyperlipidemic and 1 for the activity of physical exercise. The groups with anti hyperlipidemic medication and without medication by exposing to physical exercise are compared in one aspect and however the group treated with methanolic extract showed better activity than standard and other groups.

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