PHARMACOLOGICAL SCREENING OF TERMINALIA BELLERICA FOR ITS ANTIPSYCHOTIC AND ANXIOLYTIC ACTIVITY ON MICE

Author(s): *M. Venkateswara Rao and R.S. Venkatesh

Abstract: Objective: To carry out the preclinical evaluation of methanolic extract of the leaves of Terminalia Bellerica for antipsychotic and anxiolytic activity. Methodology: The preclinical evaluation of standardized diazepam and methanolic extract of the leaves of Terminalia Bellerica for antipsychotic and anxiolytic activity was carried out by using the following experimental models: a) Continuous Avoidance test b) Elevated Plus Maze c) IR Actimeter d) Open field test. Results: The models for studying drugs or conditions that show antipsychotic and anxiolytic activity was standardized and evaluated by using leaf extracts of Terminalia Bellerica. The methanolic leaf extract of Terminalia Bellerica has shown significant antipsychotic and anxiolytic activity by all the employed experimental models. Conclusion: Screening models for studying drugs or conditions that affect anti-psychotic and anti-anxiety were standardized and evaluated by using methanolic extract of Terminalia Bellerica. The leaf extract has shown significant activity of antipsychotic and anxiolytic activity when compared with standard treatment group.

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