Assessment of Trace Metal Levels in the Serum of Pre and Postmenopausal Breast Cancer Patients

Author(s): Lakshminarasaiah. S*, Yathirajarao T, Sai Madhuri. V, Sivakumar Y. K

Abstract: Breast cancer is the most common malignant disease in females. It is one of the most common causes of cancer mortality in females. This study aims to prove the significance of analyzing the trace metal levels among the different stages of pre and postmenopausal breast cancer patients, which can be implicated as biomarkers to early diagnosis of breast cancer. In this case-control study, the subjects were divided into healthy controls (n = 25), three stages of Stage I (n=24+24), Stage II (n=19+19), Stage III (n=21+21) in each subject of premenopausal, postmenopausal breast cancer. The trace metal in all subjects was analyzed by atomic absorption spectrometer. It was observed that the serum means of Pb, Cd, Cr, Ni, Fe, and Cu levels were significantly increased in pre and postmenopausal breast cancer patients with clinical stages when compared to the healthy controls (P < 0.001). The results further proved the significantly decreased levels of Se and Zn in pre and postmenopausal breast cancer patients of clinical stages compared to the healthy controls (P < 0.001). Hence, it was concluded that the alteration of these trace metal levels in the serum of pre and postmenopausal breast cancer patients with clinical stage wise might be associated with increased risk and progression of breast cancer.

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