Green Spectroscopy of Entacapone in Bulk and Tablets by Hydrotrophy

Author(s): Vandana Patil*, S. S. Angadi, S. H. Kale and M. A. Patil

Abstract: Background Solubilization of poorly water‐soluble drugs has been a very important issue in screening studies of new chemical entities as well as formulation research. Hydrotropy is one of the solubility enhancement methods. Objective The primary objective of the present investigation was to employ these hydrotropic solutions to improve solubility of poorly soluble drug, without use of costlier organic solvents. Methods Entacapone is a poorly water-soluble drug which shows good aqueous solubility in 20 % Sodium acetate solution and its quantitative estimation in bulk and tablet dosage form was done by UV spectroscopic at 378 nm. Results The drug shows linearity in the concentration range of 0.5-5.0 μg/ml and good regression value 0.999 at λmax 378 nm. Statistical data proved accuracy, reproducibility and the precision of the proposed method. The presence of hydrotropic agent Sodium acetate did not interfere in the analysis. Conclusion The proposed method is a simple, cost effective, accurate and precise. The estimation of Entacapone using hydrotropy and spectroscopy can be successfully adopted for routine analysis in bulk and tablet dosage form precluding the use of organic solvents.

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