Synthesis and Anti-Microbial Activity of Novel 2-((4-Methyl-2-Oxo-2H-Chromen-7-Yl) Oxy)-N-(5-Substituted Phenyl-1H-Tetrazol-1-Yl) Acetamide Derivatives

Author(s): S. Srinivas, B. Srinivas, P. Kavitha, S. Kavitha and M. Ravinder*

Abstract: An efficient general method has been described for the synthesis of novel 2-((4-methyl-2-oxo-2H-chromen-7-yl) oxy)-N-(5-substitutedphenyl-1H-tetrazol-1-yl) acetamide derivatives 5(a-g). Compound 7-hydroxy-4-methyl coumarin (1) treated with α-bromo ethylacetate in the presence of potassium carbonate in acetone as solvent to give compound ethyl-2-(4-methyl-2-oxo-2H-chrome-7-yloxy) acetate (2), followed by treated with hydrazine hydrate to form corresponding 2-(4-methyl-2-oxo-2H-chromen-7-yloxy) aceto hydrazide (3). The compound 3 is condensed with substituted aromatic aldehydes (4) than followed by cyclization with sodium azide in dimethylformamide (DMF) and a few drops of glacial acetic acid to yield the title compounds 5(a-g). These analogs were evaluated for their anti-microbial activity against Staphylococcus aureus (Gram positive bacteria) Escherichia Coli (Gram Negative bacteria) and Aspergillus niger, Candida albicans (fungi). The analogs 5f identified as potent activity and 5c, 5d showed moderate activity against anti-microbial agents. Structural elucidation of all the newly synthesized title compounds has been established by the spectroscopic data IR, 1HNMR, mass and elemental analysis.

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