Formulation and in vitro Characterization of Propranolol Hydrochloride Extended Release Matrix Tablets

Author(s): Tulasi Ashwin Kumar* and Baddam Bhavani

Abstract: Extended release dosage forms cover a wide range of prolonged action preparations that provide continuous release of their active ingredients for a specified period of time. Propranolol hydrochloride is an anti-hypertensive agent which is used in the treatment of hypertension. The present investigation describes the preparation and evaluation of extended release matrix tablets of highly water soluble propranolol hydrochloride using different synthetic (HPMC K4M, HPMC K100M) and natural (sodium alginate, xanthan gum) polymers in which the matrix tablets were prepared by direct compression method in various drug: polymer concentration. Physical observation at room conditions (temp, RH) and Fourier transform infrared spectroscopy (FTIR) study concluded that no chemical interaction between drug and excipients used. The prepared blends were evaluated for tests angle of repose, bulk density, tapped density, compressibity index and hausner’s ratio. The tablets were analysed to determine the hardness, friability and in vitro release study was carried out. Dissolution studies were carried out in pH 1.2 HCl media and followed by pH 6.8 phosphate buffer media up to 24 hrs. In this investigation it is confirmed that the release rate from the matrix tablets which are prepared by xanthan gum were shown better release than other. The results of formulations F10 (99.63) were extend the release of propranolol HCl upto 24hrs. The formulations were found to be stable and reproducible.

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