Synthesis, Characterization and Antifungal Activity of a Series of Schiff’s bases of 2-(2-Oxo-2-Aryl) Ethyl Pyridazin-3-Thione derivatives

Author(s): M. Sumakanth*, P. V. Nageswari and K. Sruthi

Abstract: In the present investigation, a new series of Schiff bases of 2-(2-Oxo-2-Aryl) Ethyl Pyridazin-3-Thione derivatives were synthesized and screened for their antifungal activity. An efficient method is described for the synthesis of Schiff’s bases of a series 2-(2-Oxo-2-Aryl)Ethyl Pyridazin-3-Thione derivatives by the nucleophilic addition reactions of 1-Aryl-2-(3-Phenyl-6-thioxo-4,5-Dihydropyridazin-4H-1yl)ethanones which were inturn obtained from the corresponding Pyridazinones by using Phase transfer catalysis. The synthesized compounds were characterized by spectral analysis and then were screened for their antifungal activity against Candida albicans and Aspergillus flavus using agar diffusion method. The results indicated that all the compounds are potential therapeutic candidates and could be used for the treatment of various fungal infections.

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