In Vitro Antibacterial and Cytotoxicity Evaluation of Aloe Vera Associated Endophytic Fungi

Author(s): B. Sindhuja, J. Rengaramanujam, S. S. Sudha and J. Devakumar*

Abstract: Objective: The present study was aimed to evaluate in vitro antimicrobial and cytotoxicity of endophytic fungi and its metabolites. Methods: against Escherichia coli, Stapylococcus aureus, Klebsiella sp, Salmonella sp, Proteus sp, Shigella sp, Candida albicans, Cryptococcus sp, Trychophyton sp, and Penecillium sp, as well as their cytotoxicity on MOLT -3 cell line. Results: Isolated endophytic fungi showed significant inhibition against test microorganisms by the method of dual culture techniques. The crude secondary metabolite of isolate showed highest zone of inhibition against test organisms and the enzyme showed moderate activity. Aloe Vera associated Aspergillus sp produce amylase enzyme which showed slight to mild antiproliferative activity on MOLT-3 cell line. Conclusion: The results of the present study, suggest that Aloe Vera associated Aspergillus sp was potential antimicrobial and antiproliferative agents.

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