Synthesis and Characterization of 2, 3-Disubstituted Quinazoline-4(3h)-Ones and Their Potential Biological Activity

Author(s): Karishma. Md*, Sattu Hemalatha and T. Maneshwar

Abstract: In the present study, a series of novel 2, 3-disubstituted quinazoline-4(3h)-ones are prepared by condensation of the anthranilic acid with acetic anhydride or benzoyl chloride to get 2-methyl-(4H)-benzo[1,3]oxazin-4-one(3) or 2-phenyl-(4H)- benzo[1,3]oxazin-4-one (5). These are reacting with substituted amines to get title compounds (7a-7g and 8a-8g) and characterized by FTIR, 1H-NMR, Mass spectroscopy. Further, the compounds were screened for the anti-tubercular activity of the synthesized quinazolinones (7a-7g & 8a-8g) was screened against M. tuberculosis H37 RV strain in the Middlebrook 7H9 (MB 7H9 broth) by using Streptomycin and Pyrazinamide as standard drug. The higher anti-tubercular activity of compounds 7b & 8c having thioamido, and guanidino groups exhibited more activity.

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