Phytochemical and in Vitro and in Vivo Evaluation of Anti Diabetic Activity of Tecomaria capansis Extract of Leaves in Wistar Albino Rats

Author(s): SK. Mallika*, S. Manohar Babu, K. Vadivel, Fathima Asra, Ch. Puja, P. Sabira and B. Prasanna Kumar

Abstract: Diabetes mellitus is a metabolic issue at first recognized by lost glucose homeostasis, because of disturbances of carbohydrate, fat and protein digestion, coming from imperfections in insulin generation, emission, insulin activity. Diabetes comprises in two types; Type I and Type II. Most hypoglycemic plant constituents, such as alkaloids,phenolic acids and amino acids, inhibit insulinase in vitro and are hypoglycemic in vivo in normal rats. The wide kind of chemical classes indicates that a variety of mechanisms might be involved in the lowering of the blood glucose level. Our results shown that oral administration of Tecomariacapensis extract has a beneficial effect on the reducing hyperglycaemia, SGOT & SGPT levels, total cholesterol, triglycerides levels, LDL-cholesterol, VLDL-cholesterol and improving the HDL status. This study suggests that the induction of diabetes mellitus may be prevented by flavonoids of plant constituent’s administration. There is a need to continue to explore the mechanisms for anti-diabetes.

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