A Retrospective Study on Importance of CRP as a Predictor and to Analyze the Effectiveness of Antibiotics in the Treatment of Neonatal Sepsis at Karpaga Vinayaga Institute of Medical Sciences and Research Centre

Author(s): B. Prathap* and P. Jacob Verghese

Abstract: Aim: Early diagnosis of sepsis in a neonate is often difficult because symptoms and signs are usually non-specific. A study was conducted to evaluate C-reactive protein (CRP) as a screening tool and the effectiveness of anti-biotics in the treatment of neonatal sepsis. Methods: The retrospective study was conducted at Karpaga Vinayaga Institute of Medical & Research Centre, from June 2016 to December 2016, on total of 120 neonatal sepsis patients. Patients of Group I received Ampicillin + Gentamicin, Group II received Ampicillin + Gentamicin followed by Cefotaxime + Amikacin, Group III received Cefotaxime + Amikacin, Group IV received Ampicillin + Gentamicin followed by Piptaz followed by Amikacin + Ciprofloxacin and Group V received, Ampicillin+ Gentamicin followed by Piptaz then by Amikacin + Meropenem and then by Ciprofloxacin. Chi-square test two side p-value and ONE-WAY ANOVA followed by Tukey-Krammer Multiple Comparison Test is used for statistical analysis. Results: Among study subjects, 18 (15%) and 102 (85%) had negative and positive CRP respectively. According to blood culture studies, 15 cases were culture positive, with the following organisms, Klebsiella pneumoniae (53.33%), Escherichia coli (20%), Staphylococcus aureus (20%) and Proteus marbilis (6.66%). Group II is an appropriate choice for empirical therapy of neonatal sepsis and was 46.96% of 66 patients. Group I, which is considered as First Line treatment was 33.33% of 66 patients. Conclusion: CRP is a highly sensitive parameter in detection of cases with neonatal sepsis. The most effective treatment was found out as Group I and Group II.

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