Methanol Extract of Gomphrena celosioides Leaves Affects Inflammatory Markers in Acidified Ethanol-Induced Gastric Ulcer Healing in Male Wistar Rats

Author(s): *Tijani Abiola Stephanie, Biochemistry Department, Bowen University, PMB 284, Iwo, Osun State, Nigeria.

Abstract: Neutrophil infiltrations and free radical mediated processes have been reported to delay gastric ulcer healing in ethanol-induced gastric ulcer. This study investigated the potential of the methanol extract of Gomphrena celosioides (MEGC) leaves in the healing of ethanol-induced gastric ulcer in male Wistar rats. Thirty-six rats were divided into six groups of six rats each and treated orally. Group 1 rats served as control group and received 1 ml/kg body weight of 1% gum acacia solution; groups’ 2-6 rats were given acidified ethanol to induce gastric ulcer. Groups 3, 4 and 5 rats were treated with 200, 400 and 800 mg/kg body weight of MEGC leaves while group 6 rats were treated with 50 mg/kg body weight of cimetidine (CIM) for fourteen days after ulcer induction. Ulcerogenic parameters, inflammatory markers and the levels of lipid peroxidation and protein carbonyl were determined. Acidified ethanol caused severe gastric mucosa damage as revealed by the ulcerogenic parameters with increased activities and concentration of the inflammatory markers and concomitant increase in the levels of lipid peroxidation and protein carbonyl in the ulcerated untreated group, but healing were accompanied by a significant decrease in these observations with different doses of MEGC or CIM for 14-days. MEGC significantly heal the ulcer with percentage ulcer healing of 34.79%, 39.63%, and 53.81% for different at doses and CIM 58.49% respectively. Our findings thus revealed that administration of MEGC leaves promote gastric ulcer healing by suppressing the inflammatory markers could be relevant in the pathologies involving gastrointestinal disorder.

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