Formulation and Evaluation of Taste Masked Oro-Dispersible Dapoxetine Hydrochloride Tablet

Author(s): Vishal S. Gujare and Avinash B. Gangurde

Abstract: To developed Oro-dispersible tablet of Dapoxetine hydrochloride for premature Ejaculation treatment.The bitter taste of drug should be masked in order to formulate in luscious form. Taste masked of bitter taste of Dapoxetine hydrochloride by solid dispersion technique. The prepared by solid dispersion of Dapoxetine hydrochloride with Eudragit E-100 in various drug:complex ratio, formulation in to Orodispersible tablet, using superdisintegrants SSG, CP, CCS in different concentration. Oro-dispersible tablet was formulated and evaluated of thickness, weight variation, hardness, friability, drug contain, wetting time, water absorbtion ratio, In-vitro release time and disintegration time. Dapoxetine hydrochloride and excipients used in study were found compatible. fast dissolving taste masked Oro-dispersible tablet of Dapoxetine hydrochloride was successfully develop. Among three developed solid dispersion Dapoxetine hydrochloride: Eudragit E-100 (1:1) was possessed no disagreeable taste. Among developed nine formulation of Dapoxetine hydrochloride solid dispersion (1:1), formulation-F6 contain crosspovidone released 98.36±1.26% drug within nine min. which was found as best formulation.

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