Syed Abdul Azeez Basha1 and Salma Begum*

Author(s): Syed Abdul Azeez Basha and Salma Begum*

Abstract: Candesartan Cilexitil is an Angiotensin II receptor antagonist used in the treatment of hypertension. But it exhibits poor water solubility and extensive first pass metabolism. This study aims to focus on development of oral disintegrating films containing solid dispersions of Candesartan Cilexetil with an objective of improving its water solubility and offering a rapid as well as a prolonged delivery coupled with enhanced therapeutic efficacy, patient compliance and the bioavailability. First the solid dispersions were prepared by fusion method using mannitol as a carrier in different ratios of 1:1, 1:2, and 1:3. Then oral disintegrating films of candesartan were prepared by solvent casting method using film forming polymers like PVA, HPMC-E5 and sodium alginate of different concentrations. Prepared films were evaluated for their Weight, Thickness, Surface pH, Drug content uniformity, in vitro disintegration time, folding endurance, in vitro drug release and stability studies. Six formulations were prepared of which F3 formulation containing HPMC-E5 was found to be as optimised with in vitro drug release of 98.91±0.73% within 10 mins and disintegration time of 21.33±1.52 secs. Results from stability studies indicate that the formulated oral disintegrating films are stable and no remarkable changes were observed.

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