Formulation Development and in vitro Evaluation of Escitalopram Immediate Release Tablets

Author(s): Swathi A, Goverdhan Reddy P, Prasad G, Srinivas A and Ismail MD*

Abstract: The aim of this study is to formulate and significantly improve the bioavailability and reduce the side effects of immediate release tablets Escitalopram. The precompression blends of Escitalopram were characterized with respect to angle of repose, bulk density, tapped density, Carr’s index and Hausner’s ratio. The precompression blend of all the batches indicates good to fair flow ability and compressibility. Immediate release tablets were prepared with various polymers like PEG 6000, Croscarmellose sodium and Sodium-starch glycolate at different concentration ratios and were compressed into tablets. The formulated tablets were evaluated for various quality control parameters. The tablets were passed all tests. Among all the formulations F7 formulation containing, drug and Croscarmellose sodium showed good result that is 98.12 % in 45 min. Hence from the dissolution data it was evident that F7 formulation is the better formulation. By conducting further studies like in vitro studies.

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