Study of Variation in Electrochemical Behavior of Metronidazole and Norfloxacin Simultaneously by Differential Pulse Voltammetry

Author(s): V. M. Wagh*

Abstract: In present study, a successful attempt has been made to study the variation in electrochemical behavior of Metronidazole and Norfloxacin simultaneously using Differential Pulse Voltammetry (DPV) technique. The effect of different pH (2-10) of Britton-Robinson Buffer on voltammogram using 1M KCl as a supporting electrolyte was studied. The optimum pH was found to be pH 6.5. Both Metronidazole and Norfloxacin exhibited reduction cathodic peak at optimum pH with peak potential at -0.46 V for Metronidazole and -1.30 V for Norfloxacin vs. S.C.E. 0.1N CH3COOH was used as Solvent for the analysis. The variation in electrochemical behavior of Metronidazole and Norfloxacin simultaneously at the optimized pH was studied by varying pulse amplitude and scan rate. The optimized pulse amplitude was found to be 50mV and the optimized scan rate was found to be 15 mV/s.

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