Anti-Oxidant and Anti-Nociceptive Activity of Ethanolic Leaf Extract of Vitis vinifera

Author(s): Medapati Sridevi*, Ruttala Susheel Kumar, Bhagavatula Sai Pranavi And Sabbella Venkata Prasanna

Abstract: Aim: Evaluation of Antioxidant and Anti nociceptive activity of ethanolic leaf extract of vitis vinifera. Materials and methods: In the present study the effects of ethanolic extract of Vitis vinifera on pharmacological changes of Albino rats in normal and pain induced rats was investigated. The animals were divided into 3 group’s control, low dose (75mg/kg) and high dose (150mg/kg). Rats in each of these groups were sub divided into 2 groups ie. with pain and without pain. The rats of each group were tested on Eddy’s hot plate apparatus. Results: The results showed reduced pain in rats treated with vitis vinifera extract when compared with control group. The in vitro antioxidant activity was carried out to correlate its protective effect against oxidative stress, significant inhibition against DPPH and Nitric oxide radicals were observed with extract in dose dependent manner and the results were compared with that of standard Gallic acid.

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