Design and Evaluation of Nystatin Emulgel For Superficial Skin Infection

Author(s): Rathod Sohan* and Mukesh T. Mohite

Abstract: Candida infection of skin, nails and vagina are very common worldwide. Cutaneous candidiasis is superficial mycotic infection of skin caused by the yeast candida albicans. Nystatin is a polyene antifungal characterized by broad spectrum of antifungal action including a wide range of pathogenic and non-pathogenic yeast & fungi. Nystatin is active against fungal pathogen including: candida, aspergillus, histoplasma, and coccidiosis’s and has been used for yeast treat candida at the skin and those for mouth. Nystatin that interference with permeability of the cell membrane of sensitive fungi by binding to sterol, chiefly ergosterol. Its main action is against candida Albicans. Nystatin is come under BCS IV class drug having lower solubility & lower permeability made several challenges on topical formulation. Lower solubility & lower permeability can affect Bioavailability, permeability, penetration of drug as well as drug dissolution/diffusion study. The Aim of this study is improving Nystatin solubility, Dissolution rate & subcutaneous absorption to increase its efficacy for topical applications. This is achieved by gel-based emulsion-based gel. The emulsion-based gel has considered as one of the high advertence delivery system as it has binary release system which are gel and emulsion. The neem oil has an antibacterial and antifungal as well as antibacterial properties it has inhibitory action against candida albicans & aspergillus Niger.

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