Potential Probiotic Therapy for the Prevention of Antibiotic Associated Diarrhoea by using Lactobacillus Strain L9 Isolated from Soibum

Author(s): Joyshree Kshetrimayum1, Poorna Chandra Rao, M Y Sreenivasa, R.K. Rajeshwari Devi, Oinam Premila Chanu

Abstract: Antibiotic associated diarhoea (AAD) is defined as an unexplained diarrhoea that occurs in association with the administration of antibiotics. Enteric pathogens like Salmonella, Clostridium perfringens type A, Staphylococcus aureus, Escherichia coli, Staphylococcus aureus, Salmonella enterica, Shigella flexneri, Vibrio cholerae and Enterobacter aerogenes and possibly Candida albicans has been associated with antibiotic- induced diarrhea. Probiotics commonly administered in randomized controlled trials of AAD are: Lactobacillus acidophilus, Lactobacillus bulgaris, Lactobacillus casei, Lactobacillus rhamnosus, Bifidobacteria bifidum, Bifidobacteria longum, Streptococcus thermophiles, Saccharomyces boulardii. The isolate L9 from soibum was found to be effective against the enteropathogens. The efficacies of commercially available antibiotics for AAD were also found to be increased when incorporated along with the isolate. This technique of using the isolate along with the antibiotics could be useful in the treatment of antibiotic resistant pathogens.

PAGES: 1419-1431  |  280 VIEWS  367 DOWNLOADS