Prospective Observational Study of Common Organisms Causing Neonatal Sepsis and Its Antibiotic Sensitivity in Sick Neonatal Care Unit, Tiruppur

Author(s): R. Dinesh Kumar*, Priestly John George, Reshna V, Simi T Anil, P. Dhanabal and V. Ganesan

Abstract: Background: Neonatal sepsis is a major cause of mortality and neurodevelopmental impairment among neonates. It contributes to nearly 30 % of neonatal deaths in developing countries. Increased prevalence of extended spectrum beta- lactamases (ESBLS) and methicillin-resistant Staphylococcus aureus (MRSA) and multiple drug resistant (MDR) strains is a cause of concern in neonatal intensive care units (NICU) worldwide. Objectives: To identify most common organism causing sepsis and also to analyse the most sensitive antibiotics against specific microorganism and to compare the different organism with different antibiotic sensitivities. Materials and methods: The study is based on a prospective analysis of all cases admitted to the neonatal intensive care unit (NICU) of Govt. Head Quarters Hospital Tiruppur, Tamil Nadu. The study was carried out from February to August 2019. Results: In our study out of 50 patients studied, Gram-negative organisms were isolated in 30 cases (60%), Gram-positive in 20 cases (40%). The most gram-negative organism which caused neonatal sepsis was Klebsiella Pneumonia 9 cases (45%) and of gram-positive organism was Staphylococcus Spp 10cases (50%). Amikacin and meropenem was the most sensitive antibiotic active against gram positive and gram-negative microorganisms respectively. Conclusion: Blood culture is the gold standard in diagnosis and treatment of neonatal septicaemia. Multiple antibiotic resistances among neonatal sepsis are currently one of the greatest challenges to the effective management of infections. Therefore, we suggest that surveillance of antimicrobial resistance is necessary.

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