Pharmacognostical and Pharmaceutical Analysis of Dhatri Bhallataka vati- For Primary Adult Hypothyroidism (Research Article)

Author(s): Pooja Abhani*, Mandip Goyal, Harish C.R. and V.J. Shukla

Abstract: Dhatri Bhallataka Vati is a polyherbal formulation containing various Ayurvedic medicinal drugs and is mentioned in Aayurveda Nibandhamala, specially indicated for the treatment of Ama, Ajirna, Gulma and in the condition of Agnimandhya. Hypothyroidism is a clinical syndrome resulting from deficiency of thyroid hormones due to their insufficient synthesis which in turn results in a generalized slowing down of metabolic processes. It affects the metabolism of the body even at cellular level and can affect any organ virtually. Dhatri Bhallataka Vati can be a promising formulation in the management of hypothyroidism. In the present study, an attempt has been made to develop pharmacognostical and pharmaceutical standards for Dhatri Bhallataka Vati. For assurance of quality of herbal compounds pharmacognostical and pharmaceutical analysis should be done. Methods: Dhatri Bhallataka Vati was subjected to microscopic evaluation for pharmacognostical study, physic-chemical analysis like hardness, weight variation, loss on drying, ash value, acid insoluble extract, pH value, water soluble extract, alcohol soluble extract, and high Performance thin layer chromatography(HPTLC). Results: Pharmacognostical study showed the presence of certain identifying characters of all of the ingredients of Dhatri Bhallataka Vati that is Amalaki, Bhallataka, Shunthi, Pippali, Maricha, Haritaki, Bibhitaki, Krishna Tila and Purana Guda. In pharmaceutical study, preliminary physico-chemical analysis showed that hardness of Vati was 3.5 Kg/cm2, ash value 07.95%w/w, loss on drying 06.01%w/w, water soluble extract 26.44%w/w, alcohol soluble extract 30.60%%w/w. HPTLC analysis showed eleven spots in 254nm and eight spots in 366nm. Conclusion: Present work was carried out to standardize the polyherbal formulation Dhatri Bhallataka Vati in terms of its identity, quality and purity. Pharmacognostical and physico-chemical observations revealed the specific characters of all active constituents in the preparation.

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