Effect of Bisphosphonates on Bone Mineral Density in Postmenopausal Women with Osteoporosis: A Retrospective Study (Research Article)

Author(s): Kusam Harika*, Marlabeti Prathyusha, Surepalli Divya Sree, Rentala Praveen, V. Suresh and Singanamala Suman

Abstract: Aim: The aim is to study the effect of Bisphosphonates on Bone Mineral Density in Postmenopausal women with Osteoporosis. Methodology: A retrospective study was conducted in department of Endocrinology for a period of 6 months in a tertiary care hospital. Postmenopausal women with Osteoporosis received treatment with Bisphosphonates along with Calcium and Vitamin-D Supplements were included, patients with Chronic kidney disease, Gastro-oesophageal Reflux disease, Liver disease were excluded in the study. Results: In a total of 59 patients, this study was demonstrated a statistically significant improvement in mean BMD (5.36% and 4.06%) at Lumbar spine and hip respectively (P<0.001 at both sites), but statistically non-significant improvement in mean BMD (2.1%) at Forearm (P value -0.929). In T-Score, an identical pattern was observed to the BMD changes in all sites namely improvement in all vertebrae, Trochanter, and total hip and no change in Neck of Femur and various Forearm sites. Conclusion: In our study, we concluded that the treatment with Bisphosphonates is associated with improvement in Bone mineral density and T-Score of Lumbar spine and Hip. Treatment with Bisphosphonates is associated with maintenance of Bone mineral density and T-Score of Femoral neck and Forearm leading to an improvement in Z-Score.

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