Neuroprotective Effect of Orthosiphon thymiflorusroth on Haloperidol Induced Parkinson Disease in Animal Models (Research Article)

Author(s): Aditi Sharma* and Ravindra Babu Sajja

Abstract: Objective: The aim of the present work was to investigate anti-Parkinson’s activity of Orthosiphon thymiflorus Roth ethanolic extract (OTEE) in haloperidol induced experimental animal models. Material and Methods: The experiment was designed by giving haloperidol to induce catalepsy and to induce Parkinson’s disease-like symptoms. The effects of Orthosiphon thymiflorus (200, and 400 mg/kg, p.o.) were studied using in vivo behavioral parameters like catalepsy, muscle rigidity, locomotor activity and antioxidant activities in rats. Results: The increased cataleptic scores were significantly (P<0.05) found to be reduced with the OTEE at a dose of 200 and 400 mg/kg. OTEE administration showed significant increase in lipid peroxidation level and depleted catalase, and reduced glutathione level. Daily administration of OTEE (400 mg/kg) also significantly(P<0.05) improved motor performance and increase locomotor activity. Conclusion: The present study was confirmed that prepared extract was significantly attenuated the motor defects and also protected the brain from oxidative stress.

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