Synthesis and Evaluation of 4-Alkyl /Aryl/Heteroaryl 3, 5-Bis-N-(4-Chloro Phenyl) Carbamoyl 2, 6-Dimethyl 1, 4-Dihydropyridines (Research Article)

Author(s): Venu Madhav Neerati, Srinivas Nayak Amgoth* and Chinna Eswaraiah

Abstract: A new carbamoyl series of 1,4-dihydropyridines were synthesized from the condensation reaction of N-(4-chlorophenyl) acetoacetamide, ammonium acetate and appropriate aliphatic, aromatic or hetero aromatic aldehyde by conventional and microwave irradiation methods. The synthesized compounds were purified and confirmed by IR, 1HNMR and Mass spectral data. The methods employed have been compared in terms of yields, reaction times. All the experimental conditions in MWI method, when compared to conventional, are easy simple, eco-friendly and the reactions are rapid and high yielding. The synthesized compounds have been evaluated for their cytotoxic activity against MCF-7 (breast cancer) HeLA (cervical cancer), and HT-29 (colon cancer) cell lines and antimicrobial activity against Staphylococcus aureus Escherichia coli and Candida albicans. Among the series compounds containing heterocyclic as carbamoyl derivatives exhibited more cytotoxic and antimicrobial activities, remaining compounds could exhibit some degree of cytotoxicity but not at all comparable with that of the standard.

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