Retrospective Study of Proton Pump Inhibitors Induced Vitamin B12 Deficiency and Their Management (Research Article)

Author(s): R. Dinesh Kumar*, J. Jemimah Jane, H. Rajamohamed and S. Mohamed Akram Ali

Abstract: Aim and Objectives: We undertook this study aiming to investigate the association between PPIs use for 2 years and potential changes in iron and vitamin B12 status and to study the efficiency of treatment. Methods: Retrospective case-control study was conducted within a sample of 240 people of the Indian population aged 18 and older from the Tirupur government hospital. Results: Statistical analyses revealed a significant change that vitamin B12 deficiency was more likely among users of gastric acid inhibitors in young people and in women on the basis of gender. Discussion: A study based on a sample of 240 adult patients about assessing the appropriate use of PPIs among the Indian population indicate significant changes in VitaminB12. Conclusion: We conclude that there is a significant association between long-term PPI use and vitamin B12 deficiency, which is stronger among young age groups and among women and can be managed by proper drug treatment.

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