Phytochemical Screening and in vitro Antihelmintic Properties of Justicia betonica L.(Research Article)

Author(s): M. Prathibha and S.C. Jayaramu*

Abstract: The study was intended to evaluate the preliminary phytochemical screening and antihelmintic property of Justicia betonica L. under in vitro conditions in comparision to standard antihelmintic drug. The phytochemical analysis of the extract confirmed the occurrence of many phytochemicals and maximum being observed in methanolic extract. The in vitro anthelmintic activity carried out on mature Pheretima posthuma revealed that among the different solvent extracts evaluated, methanolic extract showed significant anthelmintic property. The methanol extract of J. betonica required a minimum of 21 min and 27 min to paralyze and cause death to P. posthuma at 10 mg mL-1 concentration, respectively. Likewise, negative results were observed in petroleum ether extract and dimethylformamide, while piperazine citrate required a minimum of 10 and 13 min to cause paralysis and death of P. posthuma at 5 mg mL-1 concentration. In addition, studies on J. betonica are required to recognize the active principle responsible for anthelmintic activity.

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