Evaluation of Anti-inflammatory and Analgesic Activity of Root Extracts of Tragia bicolor miq

Author(s): V Gomathi*, B.Jayakar, D. Umamaheswari and Sujitha P.J.

Abstract: Inflammation is a protective local response attempt by the organisms to remove the injurious stimuli and to initiate the healing process. It is a body defense mechanism in order to eliminate or limit the spread of of necrosed cell or tissue. Progressive destruction of the tissue would compromise the survival of the organism. Inflammation can also lead to a host of diseases such as hay fever, Atherosclerosis, Rheumatoid arthritis. Tragia bicolor belonging to family Euphorbiaceae is commonly used in the Ayurvedic system of medicine. The aqueous and alcoholic root extracts was evaluated for its in-vivo anti-inflammatory activity by carrageenan induced paw edema in wistar albino rats (Plethysmometer). Also evaluated for the analgesic activity by Eddy’s hot plate method and 0.6% acetic acid induced writhing response models of swiss albino mice. The oral administration of the aqueous and alcoholic root extracts at a dose of 200mg/kg and 400mg/kg were showed a significant anti-inflammatory and analgesic activities. The extracts have showed significant decrease in paw edema volume as compared to the untreated vehicle control group. The extracts caused an inhibition on writhing response induced by 0.6% acetic acid and the Eddys hot plate method also proved the analgesic activity. These effects may be due to the potentiation of its inhibitory effect on the synthesis and release of various mediators.

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