Evaluation of Nephro-Protective and Antioxidant Potential of Sterculia Foetida Linn. Leaves in Gentamicin Induced Acute Renal Failure (Research Article)

Author(s): Goutham Pruthvi S, Suresh R, Benito Johnson and Venkatanarayanan

Abstract: Gentamicin is a aminoglycoside antibiotic and it is toxic to the kidney. It induces inflammation, vascular damage and cause death to the cells of tubular epithelium. Our investigation study is to evaluate the potential of sterculia foetida linn leaves on gentamicin induced nephrotoxicity. Studies covered the etiopathology of gentamicin induced toxicity and the effects of anti-fibrotic by MESF (Methonolic extract of sterculia foetida). In this experiment Rats were divided into five group’s control, alone gentamicin, gentamicin + MESF low dose, gentamicin + MESF high dose, and standard drug. In this group gentamicin is administered 100mg/kg through i.p. MESF of low dose 200mg/kg and high dose of 400mg/kg are administered orally in a specific time. The kidneys were removed for analysis. Gentamicin transiently increased serum creatinine, urea, total protein and urine creatinine with abnormal rise and MESF prevents such rises. Quantitative analysis of histological lesions representing marked structural damage apoptosis in the gentamicin group, with the lesions being reduced by MESF treatment. MESF significantly reduced renal fibrosis compared with the gentamicin group. MESF provided protection against gentamicin-induced acute nephrotoxicity and subsequent fibrosis by reduced apoptosis and inflammation.

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