SYNTHESIS, CHARACTERIZATION AND ANTHELMINTIC ACTIVITY OF NOVEL IMIDAZOLE-5-ONE DERIVATIVES

Author(s): Chandraprakash.B* and Sarangapani.M

Abstract: Objective: To synthesize and evaluate the Anthelmintic activity of novel Imidazole derivatives. Methods: Synthesis of Benzoyl glycine derivatives involves the N-Benzoylation of equimolar quantities of substituted benzoyl chloride with glycine in the presence of aqueous NaOH (10%). Benzoyl glycine derivatives undergo Erlenmeyer condensation reaction with Substituted Benzaldehydes in the presence of acetic anhydride and anhydrous sodium acetate to yield 2-Oxazoline-5-one derivatives. It undergoes dehydration reaction with thiosemicabazide and 1- pheny-3-thiosemicabazide to yield final compound. The Anthelmintic activity of all synthesized compounds was carried by using an Indian earthworm (Pheretima posthuma). And Albendazole used as standard drug. Results: All compounds synthesized are obtained in crystalline form with good practical yield. The purity and homogeneity of compounds synthesized were determined by sharp melting points and TLC method. The chemical structures were confirmed by FTIR, 1HNMR, and Mass spectrum. Conclusion: The synthesized compound 1b, 1d and 2d showed good Anthelmintic activities whereas others exhibited significant activities.

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