Synthesis and Pharmacological activities of 2-Substituted-3-Hydro/Aryl-3, 4-Dihydro-4-Oxo-Naphtho[2,1-B] Furo [3,2-D] Pyrimidines. (Research Article)

Author(s): A.S.Nagashree, K.Kusuma, M.S.Latha, A.S.Sowmyashree and V.P.Vaidya

Abstract: The desired pyrimidines were prepared by using ethyl 3-amiononaphtho [2,1-b] furan-2-carboxylatye 1. It was treated with various acid chlorides/anhydrides to obtain corresponding acyl derivatives 2a-f, which were then hydrolyzed to get respective acids 3a-f. The 2-substituted-4H-naphtho[2,1-b] furo-m-oxazin-4-ones 4a-f, were synthesized by cyclode hydration of acids 3a-f by using acetic anhydride. The compounds 4 a-f on nucleophilic substitution reaction with aliphatic and aromatic amines afforded 2-substituted-3-hydro/aryl-3,4-dihyro-4-oxo-naphtho[2,1-b] furo[3,2-d] pyrimidines 5a-f and 6a-f respectively. The structures of newly synthesized compounds were established by analytical and spectral studies. Evaluation of antibacterial and antifungal activity of the synthesized compounds was carried out by agar well diffusion method, antioxidant activity by DPPH method. Encouraging results were obtained.

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