Formulation and Optimization of Pluronic Lecithin Organogel Containing Verapamil Hydrochloride Using Factorial Design Method (Research Article)

Author(s): Sandeep C Atrama* and Shrikant D. Pande

Abstract: The purpose of the current study was to investigate the feasibility of pluronic lecithin organogel as transdermal drug delivery system of verapamil hydrochloride. Verapamil hydrochloride is an L-type calcium channel blocker of the phenylalkylamine class. Formulations were developed using 30% oil phase and 70% aqueous phase. A 32 factorial design was applied to check the effect of independent variables, Pluronic F-127(X1) and Soya-Lecithin (X2) on the dependent variable (Y) Percentage drug release in 24hr. The formulated organogels were evaluated for physicochemical properties, and in vitro diffusion study. It was found that the pH of all the formulations is in the range of to 6-7 that suits the skin pH, indicating skin compatibility. Invitro permeation study were performed using modified KC diffusion cell. Kinetic data revealed that the drug release followed Korsemeyer-Peppas model and the mechanism of release was found to be non fickian diffusion. The search for the optimized formulation composition was carried out using the desirability function approach with Design Expert™ 11.1.2.0, criterion being one having the maximum desirability value. The suggested formulation was considered as optimized batch (VOT3). Hence, Pluronic lecithin organogel is efficient carrier for transdermal drug delivery of verapamil hydrochloride, thereby sustaining the action.

PAGES: 68-76  |  325 VIEWS  264 DOWNLOADS