Synthesis of Diazepine and Thiazepine derivatives of 1H-imidazo [4, 5-b] pyridines (Research Article)

Author(s): A. Jeyanthi, B. Kusuma and Dayakar Gade

Abstract: Benzodiazepines and Benzothiazepines are seven membered nitrogen containing heterocyclic compounds. These are important drugs possessing various biological activities. These are widely used as anticonvulsant, antianxiety, sedative, antidepressive, hypnotic and neuroleptic agents. In the present study, a novel series of 2-(4-substituted phenyl)-4-(1H-imidazo[4,5-b]pyridin-2-yl)-2,3-dihydro-1H-benzo[b][1,4]diazepines and 2-(4-substituted phenyl)-4-(1H-imidazo[4,5-b]pyridin-2-yl)-2,3-dihydrobenzo[b][1,4]thiazepines were synthesized and screened for their antimicrobial activity.

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