Field Emission Scanning Electron Microscopy (Fesem) with A Very Big Future in Pharmaceutical Research (Research Article)

Author(s): R. Senthil Prabhu*, R. Priyanka, M. Vijay and G.R. Kaviya Vikashini

Abstract: Field Emission Scanning Electron Microscope (FESEM) is a microscope that works with electrons (particles with negative charge) instead of light. These electrons are liberated by a field emission source. The object is scanned by electrons according to a zig-zag pattern. The Field Emission Scanning Electron Microscope (FESEM) provides ultra-high imaging at low accelerating voltages and small working distances. It provides resolution of the images is a low as 0.6nm at 15KV and 1.2nm at 1 kV, allowing examination of the top surface of nano powders, nanofilm and nanofiber in the wide range of applications such as mineralogy, ceramics, polymer, metallurgy, electronic device, chemistry, physics and life sciences. This system is equipped with several detectors to detect various signals such as secondary electrons (SE) detector for topographic information and back-scattered electrons (BSE) detector for materials composition contrast. Field emission SEM (FESEM) produces clear, less electro statically distorted images with spatial resolution down to 11/2 nanometer- three to six times better. Although FESEM, are large, expensive pieces of equipment. They remain popular among researchers due to their wide range of application and capabilities including the high resolution, three dimensional, detailed images they produce. This review describes about the instrumentation, operation and pharmaceutical applications with respective drug release.

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