Evaluation Of Wound Healing and Anti-inflammatory Activities of Leaves of Ziziphus oenoplia

Author(s): Anitha Potaraju*, Kumara Swamy Samanthula and Kamal Yadav Gadda

Abstract: The wound curing activity of aqueous and alcoholic extracts of Ziziphus oenoplia leaves was evaluated by excision and incision wound models on rats. The study was carried out by topical application of 5% w/w ointment of aqueous and alcoholic extracts was prepared with PEG 400 and PEG 4000 as an ointment base. The evaluated parameters were rate of wound contraction, epithelialization period, and tensile strength of tissue and compared results with Neosporin ointment as standard. The results revealed a significant decrease 8 in epithelialization time, a significant increase in tensile strength in the animals treated with aqueous and alcoholic extracts of leaves of Ziziphus oenoplia. In addition, significant activity was found in alcoholic followed by aqueous extracts then compared to control. The study concluded that both the extracts were found to possess significant wound healing activity.

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